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Peer reviewed
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Gao, Shuang; Liu, Yanyan; Jiang, Jingyu; Li, Xiaoming; Zhao, Lixia; Fu, Ying; Ye, Fei
Pest management science, September 2020, 2020-Sep, 2020-09-00, 20200901, Volume: 76, Issue: 9Journal Article
BACKGROUND Thiabendazole (TBZ) is a poorly water‐soluble benzimidazole fungicide. However, the water solubility of TBZ can be significantly enhanced by inclusion complexation with cyclodextrins. In this study, a thiabendazole/hydroxypropyl‐β‐cyclodextrin (TBZ/HPβCD) complex was synthesized and electrospinning was performed to produce a TBZ/HPβCD nanofibrous (TBZ/HPβCD‐NF) complex that improved water solubility and antifungal activity. RESULTS The formation of TBZ/HPβCD‐NF was characterized by Fourier transform infrared spectroscopy, X‐ray diffraction and nuclear magnetic resonance. The morphology of TBZ/HPβCD‐NF was studied by scanning electron microscopy. A phase solubility experiment showed that HPβCD exerted a great solubilization effect on TBZ, and TBZ/HPβCD‐NF had better antifungal activity compared to that of TBZ alone. CONCLUSIONS In summary, the solid fungicidal nanodispersion prepared in the present study is a new type of formulation that can enhance the water solubility of TBZ. This formulation, which demonstrated potential as a new fast dissolving formulation type with increased efficacy, is expected to be conducive to the sustainable development of agriculture. © 2020 Society of Chemical Industry Thiabendazole/hydroxypropyl‐β‐cyclodextrin (TBZ/HPβCD) inclusion complex was synthesized and polymer‐free electrospinning was performed to produce a TBZ/HPβCD nanofibrous inclusion complex to improve water solubility, fluorescence and antifungal activity of this complex.
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