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Mehrabi, Hossein; Hajipour, Mina; Rezazadeh‐Jabalbarezi, Fatemeh; Alizadeh‐Bami, Farzaneh
Journal of heterocyclic chemistry, September 2020, 2020-09-00, 20200901, Volume: 57, Issue: 9Journal Article
A highly efficient one‐pot synthesis of the 1,2,4,5‐tetrasubstituted imidazoles and 2,4,5,6‐tetrasubstituted pyrimidines through an arylamidine, malononitrile, and carbonyl compound by using Et3N in CH3CN at reflux conditions was developed. The nature of the carbonyl compounds were different; when the carbonyl compound was arylglyoxal or aryl aldehyde, 1,2,4,5‐tetrasubstituted imidazole and 2,4,5,6‐tetrasubstituted pyrimidine were achieved respectively.
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