E-resources
Peer reviewed
-
Huang, Jianpan; Lai, Joseph H. C.; Tse, Kai‐Hei; Cheng, Gerald W. Y.; Liu, Yang; Chen, Zilin; Han, Xiongqi; Chen, Lin; Xu, Jiadi; Chan, Kannie W. Y.
Magnetic resonance in medicine, March 2022, 2022-03-00, 20220301, Volume: 87, Issue: 3Journal Article
Purpose To optimize and apply deep neural network based CEST (deepCEST) and apparent exchange dependent‐relaxation (deepAREX) for imaging the mouse brain with Alzheimer's disease (AD) at 3T MRI. Methods CEST and T1 data of central and anterior brain slices of 10 AD mice and 10 age‐matched wild type (WT) mice were acquired at a 3T animal MRI scanner. The networks of deepCEST/deepAREX were optimized and trained on the WT data. The CEST/AREX contrasts of AD and WT mice predicted by the networks were analyzed and further validated by immunohistochemistry. Results After optimization and training on CEST data of WT mice, deepCEST/deepAREX could rapidly (~1 s) generate precise CEST and AREX results for unseen CEST data of AD mice, indicating the accuracy and generalization of the networks. Significant lower amide weighted (3.5 ppm) signal related to amyloid β‐peptide (Aβ) plaque depositions, which was validated by immunohistochemistry results, was detected in both central and anterior brain slices of AD mice compared to WT mice. Decreased magnetization transfer (MT) signal was also found in AD mice especially in the anterior slice. Conclusion DeepCEST/deepAREX could rapidly generate accurate CEST/AREX contrasts in animal study. The well‐optimized deepCEST/deepAREX have potential for AD differentiation at 3T MRI.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.