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Santos‐García, D.; Deus Fonticoba, T.; Suárez Castro, E.; Aneiros Díaz, A.; Catalán, M. J.; Alonso‐Frech, F.; Jesús, S.; Pastor, P.; García Caldentey, J.; Planellas, L. L.; Martí, M. J.; Caballol, N.; Martí Andrés, G.; Cabo, I.; Ávila Rivera, M. A.; López Manzanares, L.; Redondo, N.; Martinez‐Martin, P.; Astrid Adarmes, Daniela; Almeria, Marta; Alonso Cánovas, Araceli; Arnáiz, Sandra; Ascunce Vidondo, Arancha; Bernardo Lambrich, Noemí; Bejr‐Kasem, Helena; Blázquez Estrada, Marta; Botí González, Maria Ángeles; Cabello González, Carolina; Cámara Lorenzo, Ana; Carrillo Padilla, Francisco José; Casas, Elena; Clavero, Pedro; Cortina Fernández, A.; Cots Foraster, Anna; Crespo Cuevas, Ane; Cubo, Esther; De Fábregues‐Boixar, Oriol; Díez Fairen, M.; Erro, Elena; Fernández Guillán, Noelia; García Campos, Cristina; García Moreno, Jose Manuel; Gastón, Itziar; Gómez Garre, María del Pilar; González Aloy, Javier; González Aramburu, Isabel; González Ardura, Jessica; González García, Beatriz; González Palmás, Maria Josefa; González Toledo, Gabriel Ricardo; Golpe Díaz, Ana; Grau Solá, Mireia; Guardia, Gemma; Horta Barba, Andrea; Infante, Jon; Kurtis, Mónica; Labrador Espinosa, Miguel Ángel; Lacruz, Francisco; Lage Castro, Melva; Legarda, Inés; López Ariztegui, N.; López Díaz, Luis Manuel; López Seoane, Balbino; Macías, Yolanda; Mata, Marina; Meitín, Maria Teresa; Menéndez González, Manuel; Méndez del Barrio, Carlota; Miranda Santiago, Javier; Moreno Diéguez, Antonio; Nogueira, Víctor; Novo Amado, Alba; Ordás, Carlos; Pagonabarraga, Javier; Pascual‐Sedano, Berta; Pérez Fuertes, Aída; Pérez Noguera, Rafael; Prats, Marian Ángeles; Puente, Víctor; Pueyo Morlans, Mercedes; Rodríguez Méndez, Luisa; Rodríguez Pérez, Amparo Belén; Roldán, Florinda; Ruíz de Arcos, María; Sánchez Alonso, Pilar; Sánchez Díez, Gema; Sánchez Rodríguez, Antonio; Santacruz, Pilar; Segundo Rodríguez, José Clemente; Seijo, Manuel; Serarols, Agustí; Sierra, María; Solano, Berta; Tartari, Juan Pablo; Valero, Caridad; Vargas, Laura; Vázquez Gómez, Ricardo; Vela, Lydia; Vives, Bárbara; Villa, Maria Dolores
European journal of neurology, July 2020, 2020-07-00, 20200701, Volume: 27, Issue: 7Journal Article
Background and purpose The objective of this study was to analyze the relationship between motor complications and non‐motor symptom (NMS) burden in a population of patients with Parkinson’s disease (PD) and also in a subgroup of patients with early PD. Methods Patients with PD from the COPPADIS cohort were included in this cross‐sectional study. NMS burden was defined according to the Non‐Motor Symptoms Scale (NMSS) total score. Unified Parkinson’s Disease Rating Scale (UPDRS) part IV was used to establish motor complication types and their severity. Patients with ≤5 years of symptoms from onset were included as patients with early PD. Results Of 690 patients with PD (62.6 ± 8.9 years old, 60.1% males), 33.9% and 18.1% presented motor fluctuations and dyskinesia, respectively. The NMS total score was higher in patients with motor fluctuations (59.2 ± 43.1 vs. 38.3 ± 33.1; P < 0.0001) and dyskinesia (63.5 ± 40.7 vs. 41.4 ± 36.3; P < 0.0001). In a multiple linear regression model and after adjustment for age, sex, disease duration, Hoehn & Yahr stage, UPDRS‐III score and levodopa equivalent daily dose, UPDRS‐IV score was significantly related to a higher NMSS total score (β = 0.27; 95% confidence intervals, 2.81–5.61; P < 0.0001), as it was in a logistic regression model on dichotomous NMSS total score (≤40, mild or moderate vs. >40, severe or very severe) (odds ratio, 1.31; 95% confidence intervals, 1.17–1.47; P < 0.0001). In the subgroup of patients with early PD (n = 396; mean disease duration 2.7 ± 1.5 years), motor fluctuations were frequent (18.1%) and similar results were obtained. Conclusions Motor complications were frequent and were associated with a greater NMS burden in patients with PD even during the first 5 years of disease duration.
