VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

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VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

Davies, Jane C; Moskowitz, Samuel M; Brown, Cynthia; Horsley, Alexander; Mall, Marcus A; McKone, Edward F; Plant, Barry J; Prais, Dario; Ramsey, Bonnie W; Taylor-Cousar, Jennifer L; Tullis, Elizabeth; Uluer, Ahmet; McKee, Charlotte M; Robertson, Sarah; Shilling, Rebecca A; Simard, Christopher; Van Goor, Fredrick; Waltz, David; Xuan, Fengjuan; Young, Tim; Rowe, Steven M

The New England journal of medicine, 10/2018, Volume: 379, Issue: 17

Journal Article

This companion article to the VX-445 report shows that VX-659, a new CFTR potentiator, when administered with tezacaftor and ivacaftor improved lung function, sweat chloride concentration, and symptoms in patients with cystic fibrosis who harbored one or two Phe508del alleles.

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