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Costas, Laura; Frias‐Gomez, Jon; Guardiola, Magdalena; Benavente, Yolanda; Pineda, Marta; Pavón, Miquel Á.; Martínez, José M.; Climent, Maite; Barahona, Marc; Canet, Júlia; Paytubi, Sonia; Salinas, Mónica; Palomero, Luis; Bianchi, Ilaria; Reventós, Jaume; Capellà, Gabriel; Diaz, Mireia; Vidal, August; Piulats, Josep M.; Aytés, Álvaro; Ponce, Jordi; Brunet, Joan; Bosch, Francesc X.; Matias‐Guiu, Xavier; Alemany, Laia; Sanjosé, Silvia
International journal of cancer, 15 December 2019, Volume: 145, Issue: 12Journal Article
Due to the anatomical continuity of the uterine cavity with the cervix, genomic exploitation of material from routine Pap smears and other noninvasive sampling methods represent a unique opportunity to detect signs of disease using biological material shed from the upper genital tract. Recent research findings offer a promising perspective in the detection of endometrial cancer, but certain questions need to be addressed in order to accelerate the implementation of novel technologies in a routine screening or clinical setting. We discuss here new perspectives on detection of endometrial cancer using genomic and other biomarkers in minimally invasive sampling methods with a special focus on public health classic screening criteria, highlighting current gaps in knowledge.
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