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Maciel, Rui M B; Bim, Larissa V; Camacho, Cleber P; Cerutti, Janete M
Endocrine-related cancer, 09/2018, Volume: 25, Issue: 9Journal Article
In a recent issue of Endocrine-Related Cancer, Castinetti et al. reported a different natural history of phaeochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) patients between Europe and South America (Castinetti et al. 2017). The authors retrospectively collected data about the phaeochromocytoma in MEN 2 patients carrying RET mutations on exons 10 and 11 in 14 countries from South America, Southern Europe, Western Europe and Central Europe. They showed that phaeochromocytoma penetrance is lower (53%) in South America compared to South Europe, Western Europe and Central Europe.
