Limited by the characteristics of drilling, the traditional straight cooling channel is difficult to provide the best cooling effect for the mold. The conformal cooling channel is more and more favored by the mold enterprises because of its excellent cooling performance. However, the current design of conformal cooling channels generally has the problems of complex, time-consuming, and error-prone design process. Inspired by the internal catheter structure of lotus root, this paper puts forward an automatic generation method of conformal cooling channel based on the basic requirements of conformal cooling channel design in engineering practice. The basic idea of this method is to slice the mold part that needs to be cooled and check the curve interference on each slice layer, so as to screen out the control points of the spline curve, and then formulate the connection strategy to obtain the spline curve, which is used as the trace line of pipe scanning, and finally form the conformal cooling channel through pipe scanning. Experimental results show that this method can significantly decrease the time of design and guide users to quickly complete the design while reducing design errors to improve working efficiency.