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Del Prete, Eleonora; Schmitt, Emmanuelle; Meoni, Sara; Fraix, Valerie; Castrioto, Anna; Pelissier, Pierre; Ceravolo, Roberto; Moro, Elena
Neurological sciences, 06/2022, Volume: 43, Issue: 6Journal Article
Introduction In Parkinson’s disease (PD), non-motor fluctuations (NMFs), especially neuropsychiatric fluctuations, often coexist with motor fluctuations (MFs) but are often under-recognized by physicians and patients. Objective To investigate the relationship between MFs and neuropsychiatric fluctuations in PD. Methods PD patients with MFs and NMFs were enrolled. The Parkinson’s Kinetigraph (PKG), a wearable device to detect MFs and dyskinesia, was used to confirm and measure MFs. The Neuropsychiatric Fluctuation Scale (NFS), a scale composed by subscores for both the ON and OFF neuropsychiatric states, was used to identify and quantify neuropsychiatric fluctuations. Patients were asked to wear the PKG for six consecutive days to identify the ON and OFF motor periods, and then to fill the NFS during the ON and OFF motor periods for three consecutive days wearing the PKG. The PKG system provided a bradykinesia score (BKS) and a dyskinesia score (DKS). Relations between BKS, DKS, and ON and OFF NFS subscores were analyzed. Results In 18 PD patients, anxiety, apathy, and depression characterized the OFF condition, whereas self-confidence, competency, and interest in doing things were typically in the ON condition. There was a positive correlation between the BKS and the OFF NFS subscores ( p = 0.036, r = 0.51), whereas no correlation was found between the DKS and the ON NFS subscores ( p = 0.38, r = 0.22). Conclusion Neuropsychiatric fluctuations temporarily matched the OFF MFs only in the OFF condition. These findings are useful to better manage OFF NMSs and support the need to further investigate associations between non-motor and motor symptoms in PD patients.
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