E-resources
Peer reviewed
-
Shingalapur, Ramya V.; Hosamani, Kallappa M.; Keri, Rangappa S.; Hugar, Mallinath H.
European journal of medicinal chemistry, 05/2010, Volume: 45, Issue: 5Journal Article
In seeking broad spectrum pharmacological activities of benzimidazole derivatives, a group of 4-thiazolidinones 5( a– j) and 1,3,4-oxadiazoles 6( a– j) containing 2-mercapto benzimidazole moiety were synthesized and screened for in vivo anticonvulsant activity by Maximal Electroshock (MES) model and antidiabetic activity using Oral Glucose Tolerance Test (OGTT). Compounds ( 5c), ( 5d), ( 5g) and ( 5i) exhibited potent anticonvulsant results and ( 6c), ( 6d), ( 6h) and ( 6i) showed excellent antidiabetic activities and also pharmacophore derived from active molecules suggested that presence of –OH group was a common feature in all active compounds. In DNA cleavage studies, compound ( 5d) cleaved DNA completely as no trace of DNA was found. On the other hand, a sharp streak was found for compounds ( 5c), ( 6a) and ( 6d). Synthesis and broad spectrum pharmacological activities such as in vivo anticonvulsant, antidiabetic and DNA cleavage studies of benzimidazole derivatives have been studied. Compounds were characterized by spectroscopic studies and elemental analysis. Display omitted
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.