This communication discusses the Marangoni convection of hybrid nanofluid. Hybrid nanofluid is made up of two nanoparticles (MnZiFe2O4-NiZnFe2O4) and one base fluid (H2O). Darcy Forchheimer porous medium effect is inserted in momentum equation. Entropy generation in the flow due to heat transfer irreversibility, mass transfer irreversibility and viscous dissipation irreversibility is calculated and examined against pertinent parameters. Activation energy effect is applied in concentration equation. Bejan number effect is calculated to examine that which irreversibility factor is dominant. Transformations are applied to form the required governing equations from PDE’s. Effect of pertinent parameters on velocity, concentration, skin friction, temperature, entropy generation, Nusselt number and Bejan number are studied graphically. Velocity of the fluid is decreasing due to increase in porosity parameter, Forchheimer number and Marangoni ratio parameter. Temperature rises for Eckert number and nanoparticles volume fraction of both nanoparticles. Concentration rises for activation energy parameter and reduces for chemical reaction parameter. Entropy generation increases for Marangoni ratio parameter, diffusion parameter and Brinkman number.