E-resources
Peer reviewed
-
Handisurya, Alessandra; Steiner, Georg E.; Stix, Ursula; Ecker, Rupert Ch; Pfaffeneder-Mantai, Sabine; Langer, Dina; Kramer, Gero; Memaran-Dadgar, Nima; Marberger, Michael
The Prostate, 1 December 2001, Volume: 49, Issue: 4Journal Article
Background Pro‐inflammatory interleukin (IL)‐15 plays a major role in host defense and chronic inflammation by stimulating T‐lymphocyte recruitment and growth. Expression of IL‐15 and IL‐15 receptor (IL‐15R) in human prostate was examined. Methods Normal and benign hyperplastic (BPH) prostate specimens (n = 23) were analyzed for IL‐15 and IL‐15Rα‐chain expression by immunohistochemistry and Real‐Time‐PCR/RT‐PCR. Regulation of prostatic stromal cell (PSC) IL‐15 mRNA and effect of IL‐15 on prostatic cell growth were analysed in vitro. Results In normal prostate, anti‐IL‐15 and anti‐IL‐15Rα‐chain reactivity were restricted to smooth muscle and stromal cells. However, in BPH, in addition epithelial cells frequently exhibited discrete anti‐IL‐15R and often intense, membranous anti‐IL‐15 reactivity. IL‐15/IL‐15R mRNA were detected in all prostatic cells types. In BPH tissues, IL‐15 mRNA content was variable (15‐fold). IL‐15 mRNA synthesis of PSC was significantly up‐regulated by IFN‐γ. Furthermore IL‐15 strongly stimulated the growth of BPH‐T‐lymphocytes and weakly that of carcinoma cell lines, but not of stromal cells. Conclusions Overexpression of IL‐15 and IL‐15Rα‐chain in BPH and massive proliferation of BPH‐T‐lymphocytes induced by IL‐15 suggest a role for IL‐15 in prostatic inflammation. Since IFN‐γ, a T‐lymphocyte product, stimulates prostatic IL‐15 production; chronic inflammation might be triggered by this paracrine loop. Prostate 49:251–262, 2001. © 2001 Wiley‐Liss, Inc.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.