As the observation accuracy of parameters in the ionosphere cannot be directly checked, the comparison with other observations is the main way to evaluate the data quality of satellite measurements. Through the comparative analysis between the in situ electron density (Ne) observed by the China Seismo-Electromagnetic Satellite (CSES) and Ne at about 500 km altitude detected by Qujing Incoherent Scatter Radar (ISR), it was found that the pattern of CSES Ne is consistent with that of ISR Ne, and the correlation coefficient between the two sets of data is above 0.88 for different groups according to the magnitude. The value of CSES Ne is lower than that of ISR Ne, and the median value of the ratio for the difference between the conjugate data is 84.04%. Based on the comparison in the daytime between CSES Ne and ionosonde observations in China, it was found that the trend of the two datasets is mostly similar, and the correlation coefficient in some locations can reach up to 0.7. The distribution of CSES Ne and correlation coefficients at different latitudes show that the relationship is relatively better around the peak of the equatorial ionization anomaly (EIA). The differences in the value between CSES Ne and ionosonde data also exist, the relative change of which is about 80–95% in the daytime.