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Li, Qi; Yang, Hongyu; Chen, Yao; Sun, Haopeng
European journal of medicinal chemistry, 05/2017, Volume: 132Journal Article
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the pathogenesis of AD. Several AChE inhibitors have already been used for clinical treatments. However, other than normal conditions, ACh is mostly hydrolyzed by BuChE in progressed AD. Account for an increased level of BuChE and decreased level of AChE in the late stage of AD, development of selective BuChE inhibitor is of vital importance. Up till now, compounds with various scaffolds have been discovered to selectively inhibit BuChE. Different effective anti-BuChE molecules are concluded in this review. Display omitted •This review shows on recent progress in the discovery of selective BuChE inhibitor.•Highly selective compounds are selected as examples.•As far as we concern, previous reviews focusing on this topic are very limited.
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