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Wang, Yue; Huan, Luyao; Liang, Haiyan; Ding, Xuejia; Mi, Jianguo
Chinese journal of chemical engineering, 07/2022, Volume: 47, Issue: 7Journal Article
Display omitted •A macroporous PBAT/PLGA foam was prepared using supercritical CO2.•The foam displayed suitable mechanical property for the fallopian tube stent.•A rapid biodegradation rate was observed in simulated internal environment.•Implantation in the fallopian tube verified good biocompatibility of the foam. Tubal pregnancy is a common abnormal pregnancy manifestation, and the ordinary conservative treatment of tubal adhesion usually leads to the rupture of fallopian tube, which increases the risk of a second ectopic pregnancy. To avoid this symptom, it is suitable to implant a stent to separate the adhesion. Here we prepared the PBAT/PLGA foam as the stent material using supercritical CO2 foaming technology. With uniform macroporous structure and thin-wall feature, the foam possessed low compressive modulus in prevention of the possible second injury to the fallopian tube. The introduction of PLGA 50/50 improved the biodegradable capability of the foam, with a mass loss about 20% after a 12-week hydrolysis. After implanted into the ruptured fallopian tube of the rabbit model, the foam displayed excellent biocompatibility, and provided a good support to prevent tubal adhesion. As such, this work provides the foam material as a promising candidate for fallopian tube stent to remedy the tubal adhesion.
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