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Dauriat, Gaëlle; Reynaud-Gaubert, Martine; Cottin, Vincent; Lamia, Bouchra; Montani, David; Canuet, Mathieu; Boissin, Clement; Tromeur, Cecile; Chaouat, Ari; Degano, Bruno; Bergot, Emmanuel; Sanchez, Olivier; Prevot, Gregoire; Sitbon, Olivier; Thabut, Gabriel; Belhadi, Drifa; de Beauregard, Yolande Costa; Bencherif, Amina; Humbert, Marc; Simonneau, Gerald; Laouenan, Cedric; Mal, Hervé
The Journal of heart and lung transplantation, September 2021, 2021-09-00, Volume: 40, Issue: 9Journal Article
A small proportion of patients with chronic obstructive pulmonary disease (COPD) patients present severe pulmonary hypertension (PH), defined by mean pulmonary artery pressure (mPAP) ≥35 mm Hg measured by right heart catheterization. Little is known about the characteristics of severe PH-COPD. The aim of the study based on a national registry was to describe this phenotype. We prospectively included and followed patients with incident PH-COPD. Clinical, functional, hemodynamic data at inclusion and follow-up were retrieved. Survival assessed by Kaplan-Meier analysis was the primary end-point. From 2012 to 2016, 99 patients from 13 French centers were included in the study (82 males; median age 66.0 years interquartile range 62.0-72.0). At inclusion, most patients had marked dyspnea (55.6% and 22.2% New York Heart Association class III and IV, respectively). During 12 months before inclusion, 42.9% had an exacerbation requiring a hospitalization. Pulmonary function tests showed a moderate obstructive pattern with median (interquartile range) FEV1 50.0 35.0-63.0 % predicted and low diffusing capacity for carbon monoxide, median 20.0 16.5-30.6 % predicted. The median values for PaO2 and PaCO2 on room air were 50.0 44.8-62.0 and 36.0 31.1-43.0 mm Hg. Median values of mPAP, pulmonary artery occlusion pressure, cardiac index and pulmonary vascular resistance were 42.0 37.0-48.0 mm Hg, 11.0 9.0-14.0 mm Hg, 3.0 2.4-3.6 L/min/m2, and 6.3 4.2-7.9 WU, respectively. Mean restricted survival was 15.0 13.9-16.0 months. Severe PH-COPD is characterized by moderate airway obstruction but marked dyspnea and marked hypoxemia, low DLCO and high mPAP. This phenotype is associated with poor prognosis.
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