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Ortega-Francisco, Sandra; de la Fuente-Granada, Marisol; Alvarez Salazar, Evelyn K.; Bolaños-Castro, Lizbeth Airais; Fonseca-Camarillo, Gabriela; Olguin-Alor, Roxana; Alemán-Muench, Germán R.; López-Casillas, Fernando; Raman, Chander; García-Zepeda, Eduardo A.; Soldevila, Gloria
Biochemical and biophysical research communications, 12/2017, Volume: 494, Issue: 1-2Journal Article
TGF-β type III receptor (TβRIII) is a co-receptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-βs, Bone Morphogenetic Proteins (BMP2/4) and Inhibins/Activins regulate different checkpoints during T cell differentiation. We have previously reported that TβRIII modulates T cell development by protecting developing thymocytes from apoptosis, however the role of this co-receptor in peripheral lymphocytes still remains elusive. Here we describe a detailed characterization of TβRIII expression in murine and human lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naïve and central memory T cells. TβRIII was upregulated after TCR stimulation, in parallel to other early activation markers. In contrast, natural and induced Tregs downregulated TβRIII in association with FoxP3 upregulation. Finally, anti-TβRIII blocking experiments demonstrated that TβRIII promotes TGFβ-dependent iTreg conversion in vitro, and suggest that this co-receptor may be involved in modulating peripheral T cell tolerance and could be considered as a potential target to boost T cell immune responses. •TβRIII is expressed in murine and human T lymphocytes but not on B cells.•TβRIII is preferentially expressed in naïve and central memory T cells, but it is very lowly expressed on regulatory T cells.•TβRIII is upregulated by TCR signaling, following similar kinetics to other early activation markers.•TβRIII is downregulated during iTreg induction in association with FoxP3 upregulation.
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