...we completely agree with the author that organ dysfunction during critical illness is a multilayered problem, and no single component can be pinpointed (i.e., fluids) as the sole determinant of its' evolution. ...we count with clinical evidence that support the idea that fluid administration in high-risk patients may deleteriously impact organ function during the resuscitation phase. ...pretending to develop a more granular definition or score of such a complex phenomenon has the inherent risks of oversimplification, reductionism, and rapid obsolescence. Contemporary literature also supports the idea of fluids administration in sepsis, since both early vasopressor studies 11,12, as well as restrictive fluid studies 13, have still administered fluids as an initial resuscitative intervention. ...aiming to provide a more rational and multimodal resuscitation does not imply to pursue a fluid-free strategy, since altered vasomotor tone is not the only pathological determinant of circulatory dysfunction in sepsis.