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Peer reviewed
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Hou, Wei; Dong, Hewei; Zhang, Xiang; Wang, Yan; Su, Lin; Xu, Hongtao
Drug discovery today, 08/2022, Volume: 27, Issue: 8Journal Article
Display omitted •The main organoselenium species have different structural properties.•We focus on selenium containing heterocycles and natural products.•We provide information to guide the rational design of selenium-containing drugs. The diverse pharmacological activities of organoselenium compounds are closely correlated to their ability to scavenge and induce reactive oxygen species (ROS), their intrinsic oxidative properties, and their Se(0) release property. The incorporation of selenium into small molecules, and particularly into heterocycles and natural products, has shown great potential in altering the potency and selectivity of these molecules. Therefore, selenium will play an important role in drug discovery in the near future. We summarize how different organoselenium species affect cellular oxidative stress levels, and try to correlate the structural properties of selenium-containing heterocycles and natural product derivatives to their biological activities and therapeutic applications. We also provide some information to guide the rational design of selenium-containing drugs.
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