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Picillo, Marina; Cuoco, Sofia; Amboni, Marianna; Bonifacio, Francesco Paolo; Bruschi, Fabio; Carotenuto, Immacolata; De Micco, Rosa; De Rosa, Anna; Del Prete, Eleonora; Di Biasio, Francesca; Elifani, Francesca; Erro, Roberto; Fabbri, Margherita; Falla, Marika; Franco, Giulia; Frosini, Daniela; Galantucci, Sebastiano; Lazzeri, Giulia; Magistrelli, Luca; Malaguti, Maria Chiara; Milner, Anna Vera; Minafra, Brigida; Olivola, Enrica; Pilotto, Andrea; Rascunà, Cristina; Rizzetti, Maria Cristina; Schirinzi, Tommaso; Borroni, Barbara; Ceravolo, Roberto; Di Fonzo, Alessio; Marchese, Roberta; Mercuri, Nicola B.; Modugno, Nicola; Nicoletti, Alessandra; Padovani, Alessandro; Santangelo, Gabriella; Stefani, Alessandro; Tessitore, Alessandro; Volontè, Maria Antonietta; Zangaglia, Roberta; Zappia, Mario; Zibetti, Maurizio; Barone, Paolo
Neurological sciences, 12/2019, Volume: 40, Issue: 12Journal Article
Background Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.
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