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Roveda, Antonio Carlos; Papa, Thiago Bueno Ruiz; Castellano, Eduardo Ernesto; Franco, Douglas Wagner
Inorganica Chimica Acta, 01/2014, Volume: 409Journal Article
PAMAM dendrimer functionalized with ruthenium nitrosyl complexes (NO-donors), which can release nitric oxide on a controlled way when triggered either by light irradiation or by chemical reduction. Display omitted •PAMAM were functionalized with ruthenium nitrosyl complexes in one-step synthesis.•Functionalization did not alter the ruthenium nitrosyl properties.•Nitric oxide can be released when triggered by light or by one-electron reduction.•PAMAM can storage high concentrations of NO on a single framework. The functionalization of three generations of polyamidoamine (PAMAM G0, G2 and G3) dendrimers with the NO-donor trans-Ru(NO)(NH3)4(ina)(BF4)3 (ina=isonicotinic acid) is reported. PAMAMs were modified through a peptide-type bond between the carboxyl group of the ina ligand and the dendrimer superficial amines. Compounds were characterized by FT-IR, UV–Vis, CV, DPV, 1H NMR, ICP-OES, and the structure of the complextrans-Ru(NO)(NH3)4(ina)(BF4)(SiF6)·H2O was determined by single crystal X-Ray analysis. The experimental data indicated the immobilization of 4, ∼8 and ∼27 nitrosyl complexes on the G0, G2 and G3 dendrimer’s surface, respectively, which corresponds to ∼1.0–1.43μmol NO per mg of dendrimer. FT-IR, UV–Vis and electrochemical assays suggest that the functionalization of PAMAM did not alter the coordination sphere of the ruthenium nitrosyl complex neither the formal reduction potential of RuIINO+/RuIINO0 couple regarding to the complex not attached to PAMAM. The NO release in these compounds, through light irradiation (λ=355nm) and one-electron reduction (Eu2+), was investigated.
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