This study aims to determine whether the analysis of volatile organic compounds (VOCs) in exhaled breath can be used as a non-invasive monitoring tool for diabetes patients. Here, we are reporting perovskite BaSnO3 based quick responsive and highly sensitive acetone biosensor for the sensing of low concentration acetone in the human breath. The BaSnO3 nanomaterial has been prepared by the sol-gel assisted hydrothermal method and confirmed by various characterization tools such as X-ray diffraction (XRD), Field-emission scanning electron microscopy (FE-SEM), UV–Visible absorption spectroscopy and Dynamic light scattering (DLS) analysis. XRD result reveals the cubic polycrystalline nature with space group of Fm-3 m of BaSnO3 with the average crystallite size of 24.197 nm and induced strain of 1.441 × 10-4. From the X-ray Photoelectron Spectroscopy (XPS) binding energy separation between Barium and Tin doublets are found to be 15.351 eV and 8.426 eV, which confirms the presence of Ba2+ and Sn4+ states respectively. For the exhale human breath level acetone of 1 ppm, the fabricated device shows the sensor response of 6.795 along with the fast performance with 3.325 s response time. The highest sensing response was found 45.850 for 50 ppm of acetone at 80 °C operating temperature and such sensing device shows the excellent linearity between blood glucose level and sensor response. Display omitted •This research reports the monitoring of blood glucose levels by exhaling breath analysis.•The chemiresistive sensor based on BaSnO3 nanorods shows the response of 45.85 to acetone.•An excellent linearity for the blood glucose level and acetone level in exhaled human breath.•This sensor device exhibits fast performance within 3.32 s response time.