Lost in the jungle: new hurdles for optic nerve axon regeneration

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Lost in the jungle: new hurdles for optic nerve axon regeneration

Pernet, Vincent; Schwab, Martin E

Trends in neurosciences (Regular ed.), 07/2014, Volume: 37, Issue: 7

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Highlights • The regeneration of long axons in the injured CNS is a ‘holy grail’ in neuroscience. • Strong axonal growth is promoted by modulating growth genes in injured neurons. • Complete axonal regeneration is still impossible in the optic nerve injury model. • Axonal misguidance may be a major limitation for long-distance axonal regeneration. • Balanced growth-promoting treatments and axonal guidance mechanisms are required.

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