Endothelial NADPH oxidases: which NOX to target in vascular disease?

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Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, Grant R; Sobey, Christopher G

Trends in endocrinology and metabolism, 09/2014, Volume: 25, Issue: 9

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Highlights • Endothelial cells express four NADPH oxidase isoforms: NOX1, 2, 4, and 5. • NOX1, 2, and 5 make superoxide and cause endothelial dysfunction and vascular disease. • NOX4 generates hydrogen peroxide and exerts protective effects on the vessel wall. • Selective inhibitors of NOX1/2 (e.g., apocynin) hold promise as novel therapies for vascular disease.

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Drummond, Grant R | Sobey, Christopher G

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