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Moke, Diana J.; Oberley, Matthew J.; Bhojwani, Deepa; Parekh, Chintan; Orgel, Etan
Pediatric blood & cancer, February 2018, Volume: 65, Issue: 2Journal Article
While early studies reported superior survival for cancer patients enrolled on clinical trials, recent findings are inconclusive. We investigated the association between enrollment on contemporary trials and event‐free survival (EFS) in pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). In a retrospective cohort of 274 children (1–21 years) treated for B‐ALL from 2008 to 2015, 55.5% enrolled with no disparity in enrollment by age, sex, or ethnicity. Three‐year EFS was similar for enrolled and not enrolled patients (90.1% 95% CI, 82.5–94.5 versus 86.5% 95% CI, 77.7–92.0). Clinical trial enrollment did not affect pediatric B‐ALL survival, albeit in a limited‐size cohort treated at a single academic institution.
