E-resources
Open access
-
Bigot, Jeremy; Lalanne, Ana I; Lucibello, Francesca; Gueguen, Paul; Houy, Alexandre; Dayot, Stephane; Ganier, Olivier; Gilet, Jules; Tosello, Jimena; Nemati, Fariba; Pierron, Gaelle; Waterfall, Joshua J; Barnhill, Raymond; Gardrat, Sophie; Piperno-Neumann, Sophie; Popova, Tatiana; Masson, Vanessa; Loew, Damarys; Mariani, Pascale; Cassoux, Nathalie; Amigorena, Sebastian; Rodrigues, Manuel; Alsafadi, Samar; Stern, Marc-Henri; Lantz, Olivier
Cancer discovery, 08/2021, Volume: 11, Issue: 8Journal Article
Disruption of splicing patterns due to mutations of genes coding splicing factors in tumors represents a potential source of tumor neoantigens, which would be both public (shared between patients) and tumor-specific (not expressed in normal tissues). In this study, we show that mutations of the splicing factor in uveal melanoma generate such immunogenic neoantigens. Memory CD8 T cells specific for these neoantigens are preferentially found in 20% of patients with uveal melanoma bearing -mutated tumors. Single-cell analyses of neoepitope-specific T cells from the blood identified large clonal T-cell expansions, with distinct effector transcription patterns. Some of these expanded T-cell receptors are also present in the corresponding tumors. CD8 T-cell clones specific for the neoepitopes specifically recognize and kill -mutated tumor cells, supporting the use of this new family of neoantigens as therapeutic targets. SIGNIFICANCE: Mutations of the splicing factor in uveal melanoma generate shared neoantigens that are uniquely expressed by tumor cells, leading to recognition and killing by specific CD8 T cells. Mutations in splicing factors can be sources of new therapeutic strategies applicable to diverse tumors. .
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.