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Duncan, Christopher M., MD; Gillette, Blake P., MD; Jacob, Adam K., MD; Sierra, Rafael J., MD; Sanchez-Sotelo, Joaquin, MD, PhD; Smith, Hugh M., MD, PhD
The Journal of arthroplasty, 02/2015, Volume: 30, Issue: 2Journal Article
Abstract TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR = 0.98; 95% CI 0.67-1.45; P = 0.939) or adjusted odds of death (OR = 0.26; 95% CI 0.04-1.80; P = 0.171) were significant with TA administration. The major findings of this large, single center, retrospective cohort study show the odds of postoperative VTE and 30-day mortality were unchanged with TA administration.
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