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Kang, Guiying; Liu, Yuping; Li, Lingxia; Sun, Lu; Ma, Wei; Meng, Chao; Ma, Liwei; Zheng, Guohua; Chang, Cong; Wei, Hua
Chemical communications (Cambridge, England), 03/2020, Volume: 56, Issue: 2Journal Article
In this study, an efficient strategy for the synthesis of dumbbell-shaped amphiphilic copolymers with cyclic moieties as the two bells was developed and the enhanced performance of dumbbell-shaped copolymers for controlled drug release because of the simultaneous introduction of two macrocycles was disclosed. We reported herein the synthesis of a novel dumbbell-shaped amphiphilic copolymer with two macrocycles-based bells, and revealed the better performance of this polymer construct than those of the linear and tadpole-like analogues for drug release.
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