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Imagawa, Akihisa; Hanafusa, Toshiaki; Miyagawa, Jun-ichiro; Matsuzawa, Yuji
New England journal of medicine/The New England journal of medicine, 02/2000, Volume: 342, Issue: 5Journal Article
Type 1 diabetes mellitus is caused by loss of insulin-secreting capacity due to selective autoimmune destruction of the pancreatic beta cells. 1 , 2 Insulitis (i.e., mononuclear-cell infiltration of the pancreatic islets) is the direct result of the autoimmune process. Antibodies to the cytoplasm of islet cells, glutamic acid decarboxylase, insulin, and tyrosine phosphatase–like protein (IA-2 or IA-2β), which appear before the clinical onset of diabetes, are good markers of the autoimmune process. 1 , 2 Several lines of evidence have suggested that autoimmunity is not the only cause of beta-cell destruction. We and others have described young patients who presented with the abrupt . . .
