E-resources
-
Julien, Carl; Tremblay, Cyntia; Émond, Vincent; Lebbadi, Meryem; Salem, Norman; Bennett, David A; Calon, Frédéric
Journal of neuropathology and experimental neurology, 2009-January, 2009, 2009-Jan, 2009-01-00, 20090101, Volume: 68, Issue: 1Journal Article
Aging and metabolism-related disorders are risk factors for Alzheimer disease (AD). Because sirtuins may increase the life span through regulation of cellular metabolism, we compared the concentration of sirtuin 1 (SIRT1) in the brains of AD patients (n = 19) and controls (n = 22) using Western immunoblots and in situ hybridization. We report a significant reduction of SIRT1 (messenger RNA mRNA, −29%; protein, −45%) in the parietal cortex of AD patients, but not in the cerebellum. Further analyses in a second cohort of 36 subjects confirmed that cortical SIRT1 was decreased in AD but not in individuals with mild cognitive impairment. SIRT1 mRNA and its translated protein correlated negatively with the duration of symptoms (mRNA, r = −0.367; protein, r = −0.326) and the accumulation of paired helical filament tau (mRNA, r = −0.230; protein, r = −0.119), but weakly with insoluble amyloid-β 42 (mRNA, r = −0.090; protein, r = −0.072). A significant relationship between SIRT1 levels and global cognition scores proximate to death was also found (r = +0.09, p = 0.049). In contrast, cortical SIRT1 levels remained unchanged in a triple-transgenic animal model of AD. Collectively, our results indicate that loss of SIRT1 is closely associated with the accumulation of amyloid-β and tau in the cerebral cortex of persons with AD.
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.