E-resources
-
Lussier, Firoza Z.; Pascoal, Tharick A.; Chamoun, Mira; Therriault, Joseph; Tissot, Cécile; Savard, Mélissa; Kang, Min Su; Mathotaarachchi, Sulantha; Benedet, Andrea L.; Parsons, Marlee; Qureshi, Muhammad Naveed Iqbal; Thomas, Émilie M.; Shin, Monica; Dion, Laurie‐Anne; Massarweh, Gassan; Soucy, Jean‐Paul; Tsai, I‐Huang; Vitali, Paolo; Ismail, Zahinoor; Rosa‐Neto, Pedro; Gauthier, Serge
Alzheimer's & dementia, January 2020, 2020-01-00, 20200101, Volume: 16, Issue: 1Journal Article
Introduction Mild behavioral impairment (MBI) is characterized by the emergence of neuropsychiatric symptoms in elderly persons. Here, we examine the associations between MBI and Alzheimer's disease (AD) biomarkers in asymptomatic elderly individuals. Methods Ninety‐six cognitively normal elderly individuals underwent MRI, 18FAZD4694 β‐amyloid‐PET, and 18FMK6240 tau‐PET. MBI was assessed using the MBI Checklist (MBI‐C). Pearson's correlations and voxel‐based regressions were used to evaluate the relationship between MBI‐C score and 18FAZD4694 retention, 18FMK6240 retention, and gray matter (GM) volume. Results Pearson correlations revealed a positive relationship between MBI‐C score and global and striatal 18FAZD4694 standardized uptake value ratios (SUVRs). Voxel‐based regression analyses revealed a positive correlation between MBI‐C score and 18FAZD4694 retention. No significant correlations were found between MBI‐C score and 18FMK6240 retention or GM volume. Conclusion We demonstrate for the first time a link between MBI and early AD pathology in a cognitively intact elderly population, supporting the use of the MBI‐C as a metric to enhance clinical trial enrolment.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.