The synergistic influences of geometrical, mechanical and thermal mismatches between a skin‐contacting medical device and the skin may cause tissue stress concentrations and sharp temperature gradients, both of which contribute to the risk for medical device‐related pressure ulcers. In this work, we developed an innovative, integrated experimental bioengineering approach encompassing mechanical stiffness, friction and thermal property studies for testing the biomechanical suitability of a hydrogel‐based dressing in prophylaxis of injuries caused by devices. We characterised the viscoelastic stress relaxation of the dressing and determined its long‐term elastic modulus. We further measured the coefficient of friction of the hydrogel‐based dressing at dressing‐device and skin‐dressing interfaces, using a tilting‐table tribometer. Lastly, we measured the thermal conductivity of the dressing, using a heat‐flow meter and infrared thermography‐based method. All measurements considered dry and moist conditions, the latter simulating skin perspiration effects. Our results revealed that the long‐term stiffness and the thermal conductivity of the hydrogel‐based dressing matched the corresponding properties of human skin for both dry and moist conditions. The dressing further demonstrated a relatively high coefficient of friction at its skin‐facing and device‐facing aspects, indicating minimal frictional sliding. All these properties make the above dressing advantageous for prevention of device‐related injuries.