E-resources
-
Mohamed, Abdelrhman; Anoy, MD Monzurul Islam; Tibbits, Gretchen; Raval, Yash S.; Flurin, Laure; Greenwood‐Quaintance, Kerryl E.; Patel, Robin; Beyenal, Haluk
Biotechnology and bioengineering, July 2021, Volume: 118, Issue: 7Journal Article
Chronic wound infections caused by biofilm‐forming microorganisms represent a major burden to healthcare systems. Treatment of chronic wound infections using conventional antibiotics is often ineffective due to the presence of bacteria with acquired antibiotic resistance and biofilm‐associated antibiotic tolerance. We previously developed an electrochemical scaffold that generates hydrogen peroxide (H2O2) at low concentrations in the vicinity of biofilms. The goal of this study was to transition our electrochemical scaffold into an H2O2‐generating electrochemical bandage (e‐bandage) that can be used in vivo. The developed e‐bandage uses a xanthan gum‐based hydrogel to maintain electrolytic conductivity between e‐bandage electrodes and biofilms. The e‐bandage is controlled using a lightweight, battery‐powered wearable potentiostat suitable for use in animal experiments. We show that e‐bandage treatment reduced colony‐forming units of Acinetobacter buamannii biofilms (treatment vs. control) in 12 h (7.32 ± 1.70 vs. 9.73 ± 0.09 log10CFU/cm2) and 24 h (4.10 ± 12.64 vs. 9.78 ± 0.08 log10CFU/cm2) treatments, with 48 h treatment reducing viable cells below the limit of detection of quantitative and broth cultures. The developed H2O2‐generating e‐bandage was effective against in vitro A. baumannii biofilms and should be further evaluated and developed as a potential alternative to topical antibiotic treatment of wound infections. Chronic wound infections are difficult to treat using traditional approaches due to the frequent presence of bacteria with acquired antibiotic resistance alongside biofilm‐associated antibiotic tolerance. An electrochemical bandage controlled by a wearable potentiostat is designed to deliver low concentrations of hydrogen peroxide to manage wound infections. The activity of the electrochemical bandage is demonstrated in vitro against Acinetobacter baumannii biofilms.
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.