Acute dystonic reactions are characterized by involuntary contraction of the muscles of the extremities, face, neck, abdomen, pelvis or larynx, in either sustained or intermittent patterns, that lead to abnormal movements or postures 1. These reactions are common with drugs that block dopamine D2 receptors, causing dopaminergic-cholinergic imbalance in the basal ganglia. These include typical antipsychotics; some atypical antipsychotics, such as risperidone and olanzapine; antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs); and some antiepileptic drugs, such as carbamazepine and phenytoin. Bupropion belongs to a group of aminoketones used widely for major depressive disorders, smoking cessation and sexual dysfunction secondary to SSRIs. KCI Citation Count: 1