Objective We sought to assess feasibility and perioperative outcomes for laparoendoscopic single-site surgery (LESS) in early endometrial cancer. Study Design This was a retrospective multicentric study of 100 early endometrial cancer cases undergoing LESS from July 2009 through July 2011. Results All patients underwent total hysterectomy and bilateral salpingo-oophorectomy by LESS. Pelvic and paraaortic lymphadenectomy were performed in 48 and 27 patients, respectively. A median of 16 pelvic lymph nodes (range, 1–33) and 7 paraaortic lymph nodes (range, 2–28) were retrieved. Both median operative time (129 minutes; range, 45–321) and estimated blood loss (70 mL; range, 10–500) were greater when staging lymphadenectomy was performed ( P values = .001). Four intraoperative and 4 postoperative complications were observed. Conversion to standard laparoscopy and laparotomy was necessary for completion of 1 case each. Patients responded positively regarding cosmetic result and minimal postoperative pain control. Conclusion LESS further minimizes the invasive nature of surgery and is feasible for treatment of early-stage endometrial cancer.