E-resources
Peer reviewed
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Yu, Ho-Sung, MS; Kang, Mi-Jin, MS; Kwon, Ji-Won, MD; Lee, So-Yeon, MD, PhD; Lee, Eun, MD; Yang, Song-I., MD; Jung, Young-Ho, MD; Hong, Kyungmo; Kim, Young-Joon, MS; Lee, Seung-Hwa, MS; Kim, Ha-Jung, PhD, DVM; Kim, Hyung Young, MD; Seo, Ju-Hee, MD; Kim, Byoung-Ju, MD, PhD; Kim, Hyo-Bin, MD, PhD; Hong, Soo-Jong, MD, PhD
Journal of allergy and clinical immunology, 03/2015, Volume: 135, Issue: 3Journal Article
Characteristic Hospital-based study Population-based study Case Control Number 1239 447 3361 Responders to questionnaire, n (%) NA NA 3299 (98.2) Age (y) 5.18 ± 3.86 9.32 ± 2.47 8.75 ± 2.90 Sex (M/F) 717/522 231/216 1719/1588 BMIlow * NA NA 17.89 ± 3.17 Lifetime AD symptoms NA NA 709 of 2349 (23.2%) Parental history of allergic diseases NA NA 1068 of 3056 (34.9%) Parental history of asthma NA NA 117 of 2911 (4.0%) Parental history of AR NA NA 953 of 3033 (31.4%) Parental history of AD NA NA 237 of 2933 (8.1%) Environmental tobacco smoking NA NA 1342 of 3095 (43.4%) Educational level of mother <=High school graduate NA NA 1242 of 3039 (40.9%) >=University graduate NA NA 1797 of 3039 (59.1%) Economic state (monthly income) Low (<3 million won) NA NA 1282 of 2977 (43.1%) Middle (3-5 million won) NA NA 1280 of 2977 (43.0%) High (>=5 million won) NA NA 415 of 2977 (13.9%) Mold exposure (visible mold) During infancy NA NA 564 of 2932 (19.2%) During the previous year NA NA 635 of 2930 (21.7%) Biomarker Total IgE (IU/mL) 512.62 ± 1095.99 57.70 ± 124.34 204.08 ± 394.16 Claudin-1 Frequency of rs9290929 A 0.933 0.953 0.946 G 0.067 0.047 0.054 Table E1 Subject characteristics Values are mean ± SD or proportion.AR, Allergic rhinitis; F, female; M, male; NA, not available. Risk factors AD Sx everlow * aOR (95% CI)dagger P value Demographic factors Sex: male 1.11 (0.91-1.34) .299 BMI 1.03 (0.99-1.06) .142 Age 0.92 (0.89-0.96) <.001 Higher economic state (monthly income >=5 million won) 1.05 (0.78-1.41) .747 Maternal education (<university graduate) 0.90 (0.73-1.12) .338 Genetic factors Parental history of allergic disease 1.70 (1.41-2.06)double dagger <.001 Parental history of AD 2.82 (2.09-3.79)double dagger <.001 Parental history of AR 1.31 (1.06-1.61) .013 Parental history of asthma 1.36 (0.87-2.13) .171 Environmental factors Environmental tobacco smoking 1.06 (0.87-1.28) .570 Pet ownership in the past 12 mo 0.89 (0.63-1.25) .490 Pet ownership during infancy 1.42 (0.94-2.14) .098 Mold exposure during infancy (visible mold) 1.60 (1.26-2.03) <.001 Biomarkers Total IgE (>200.0 IU/mL) 1.20 (0.94-1.53) .138 Table E2 Risk factors for AD in the population-based study Data were calculated by logistic regression multivariate analysis.
