Synthesis and biological evaluation of rigid polycyclic derivatives of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione

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Synthesis and biological evaluation of rigid polycyclic derivatives of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione

Ito, Felicia Megumi; Petroni, Jacqueline Marques; de Lima, Dênis Pires; Beatriz, Adilson; Marques, Maria Rita; de Moraes, Manoel Odorico; Costa-Lotufo, Letícia Veras; Montenegro, Raquel Carvalho; Magalhães, Hemerson Iury Ferreira; Pessoa, Cláudia do O

Molecules (Basel, Switzerland), 02/2007, Volume: 12, Issue: 2

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Part of our research program concentrates on the discovery of new bioactive compounds prepared either by total synthesis or molecular transformation of compounds with bioactivity profiles. In this work we have focused our interest on chemical transformations of the Diels-Alder adduct tricyclo6.2.1.0(2,7)undeca-4,9-dien-3,6-dione in order to obtain cage-like compounds and derivatives, followed by an evaluation of their biological activity.

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