List of abbreviations CMS consensus molecular subtype CRC color rectal cancer EMS epithelium/mesenchyme switches EMT epithelial-to-mesenchymal transition GO Gene Ontology GSEA Gene Set Enrichment Analysis MET mesenchymal-to-epithelial transition RFS recurrence-free survival TGF-β transforming growth factor-beta Dear Editor, To metastasize, epithelial cancer cells undergo an epithelial-to-mesenchymal transition (EMT) during migration, whereupon they activate a mesenchymal-to-epithelial transition (MET) when colonizing the new niche 1. Induction of EMS program in HT29 cells grown as spheroid regulates the cholesterol pathway and influences disease-free survival in colon cancer patients. Cholesterol is involved in multiple biological homeostatic metabolic processes (bile acids, steroid hormones and vitamin D precursors, membrane stability and rigidity, lipid raft organization). The “Cholesterol homeostasis” and the “Bile acid metabolism” pathways can be targeted by statins (β-hydroxy β-methylglutaryl-CoA HMG-CoA reductase inhibitors).