E-resources
-
Lai, Heidi T M; Imamura, Fumiaki; Korat, Andres V Ardisson; Murphy, Rachel A; Tintle, Nathan; Bassett, Julie K; Chen, Jiaying; Kröger, Janine; Chien, Kuo-Liong; Senn, Mackenzie; Wood, Alexis C; Forouhi, Nita G; Schulze, Matthias B; Harris, William S; Vasan, Ramachandran S; Hu, Frank; Giles, Graham G; Hodge, Allison; Djousse, Luc; Brouwer, Ingeborg A; Qian, Frank; Sun, Qi; Wu, Jason H Y; Marklund, Matti; Lemaitre, Rozenn N; Siscovick, David S; Fretts, Amanda M; Shadyab, Aladdin H; Manson, JoAnn E; Howard, Barbara V; Robinson, Jennifer G; Wallace, Robert B; Wareham, Nick J; Chen, Yii-Der Ida; Rotter, Jerome I; Tsai, Michael Y; Micha, Renata; Mozaffarian, Dariush
Diabetes care, 04/2022, Volume: 45, Issue: 4Journal Article
Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis. We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged ≥18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics. During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 95% CI 0.67-0.99, 0.86 0.75-0.99, and 0.84 0.74-0.96, respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P ≥ 0.1). Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.