Introduction: Endobronchial ultrasound-guidedtranbronchial needle aspiration (EBUS-TBNA) canbe applied to not only the determination of theclinical stages of lung cancer, but also thediagnosis of lymphadenopathies such as lymphomaand sarcoidosis.Case Report: We report the successful diagnosisof a combined thymic epithelial tumor in a 68-yearoldfemale by EBUS-TBNA. The patient presentedwith a 6-month history of dysesthesia in bilaterallegs. Chest computed tomography revealed a 5.5cm-tumor with heterogeneous enhancement in thesuperior and anterior mediastinum. The serumlevels of ProGRP and NSE were elevated and anti-Hu antibody was positive at the time of diagnosis.A biopsy by EBUS-TBNA revealed histologicalevidence of a combined thymic epithelial tumorconsisting of small cell neuroendocrine carcinomaand thymic carcinoma. Chemo-radiotherapyreduced the tumor remarkably in size, but thepatient’s neurologic symptoms remained.Conclusion: This case suggests that EBUS-TBNAis a safe and useful technique for the diagnosis ofparatracheal mediastinal tumors.