E-resources
Peer reviewed
-
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffoldVACCARO, Wayne D; SHER, Rosy; WILLIAMS, Shirley M; WU, Ren-Long; SHE, H. Susan; RIVELLI, Maria A; MUTTER, Jennifer C; CORBOZ, Michel R; HEY, John A; FAVREAU, Leonard; BERLIN, Michael; SHIH, Neng-Yang; ASLANIAN, Robert; SCHWERDT, John H; MCCORMICK, Kevin D; PIWINSKI, John J; WEST, Robert E; ANTHES, John C
Bioorganic & medicinal chemistry letters, 01/2006, Volume: 16, Issue: 2Journal Article
We report the discovery of novel histamine H(3) receptor antagonists based on 4-(1H-imidazol-4-yl)methylpiperidine. The most potent compounds in the series (e.g., 7) result from the attachment of a substituted aniline amide to the main pharmacophore piperidine via a two-methylene linker.
