Metagenomic next-generation sequencing for diagnosing severe leptospirosis in a patient suspected COVID-19: A case report

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Metagenomic next-generation sequencing for diagnosing severe leptospirosis in a patient suspected COVID-19: A case report

Li, Weijia; Wang, Song; Zheng, Dan

Diagnostic microbiology and infectious disease, July 2024, 2024-Jul, 2024-07-00, 20240701, Volume: 109, Issue: 3

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Leptospirosis is a zoonotic and neglected waterborne disease caused by the pathogenic helical spirochetes. Early diagnosis of leptospirosis remains challenging due to non-specific symptoms and the limited availability of rapid point-of-care diagnostic tests. Herein, we present a case where a patient suspected of having COVID-19 was diagnosed with leptospirosis using metagenomic next-generation sequencing (mNGS). This case highlights the potential of mNGS to diagnose leptospirosis in the context of the COVID-19 pandemic.

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