Improving the Drug Loading of Ondansetron Mouth Dissolving Film by the Use of Mix-Solvency Concept and In-vitro Evaluation

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Improving the Drug Loading of Ondansetron Mouth Dissolving Film by the Use of Mix-Solvency Concept and In-vitro Evaluation

Thakare, Mahesh M; Karole, Sarita

INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE, 03/2023, Volume: 14, Issue: 1

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The ondansetron oral solution fi lm was successfully prepared by the solvent casting method. The combination of HPMC E16 as a fi lm former with honey as a fi lm modifi er and PEG400 as a plasticizer produced a uniform, transparent, hard and easy to peel fi lm. The design of experiments has proven to be a very useful tool for understanding the eff ect of excipients on fi lm properties. The recipe kit powered by Stat Ease Inc. uses Design Expert 11 software trial version. The R1 formulation was found to be the best optimized group with a disintegration time of 68.0 ± 2.16 seconds and a drug release of 104.49 ± 1.06% Hanger 9 minutes.

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