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Marrakchi, Slaheddine; Guigue, Philippe; Renshaw, Blair R; Puel, Anne; Pei, Xue-Yuan; Fraitag, Sylvie; Zribi, Jihen; Bal, Elodie; Cluzeau, Céline; Chrabieh, Maya; Towne, Jennifer E; Douangpanya, Jason; Pons, Christian; Mansour, Sourour; Serre, Valérie; Makni, Hafedh; Mahfoudh, Nadia; Fakhfakh, Faiza; Bodemer, Christine; Feingold, Josué; Hadj-Rabia, Smail; Favre, Michel; Genin, Emmanuelle; Sahbatou, Mourad; Munnich, Arnold; Casanova, Jean-Laurent; Sims, John E; Turki, Hamida; Bachelez, Hervé; Smahi, Asma
The New England journal of medicine, 08/2011, Volume: 365, Issue: 7Journal Article
A study of families from southern Tunisia affected by general pustular psoriasis uncovered the genetic cause of their disease: a mutation affecting the function of the interleukin-36–receptor antagonist. Psoriasis is a chronic inflammatory skin disease affecting 2 to 3% of persons of European descent. 1 Psoriasis vulgaris, the most common form of the disease, accounts for 80% of cases and has a strong, albeit complex, genetic component. 2 Numerous chromosomal loci have been implicated in genomewide association studies, but analyses of these loci have yielded only a few candidate genes, which mediate inflammatory cytokine signaling and adaptive immune responses. 3 – 5 The disease follows mendelian transmission in a small minority of families. Generalized pustular psoriasis is a life-threatening, multisystemic inflammatory disease involving repeated flare-ups of sudden onset, which are characterized by . . .
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