E-resources
Peer reviewed
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Li, Chen; Bai, Liang; Ge, Min-Tong; Xia, Ai-Bao; Wang, Ying; Qiu, Yuan-Rui; Xu, Dan-Qian
New journal of chemistry, 08/2021, Volume: 45, Issue: 34Journal Article
We achieved chemoselective synthesis of α-alkylated arylacetonitriles and acetamides by combining Ir complex-catalysed direct coupling of alcohols and nitriles by a simple adjustment of the base. Methanol and ethanol performed well as the alkylating reagents. This method of acetonitrile alkylation provided a novel approach for carbon chain extension. Cp*IrCl 2 2 with a phosphine-free ligand α,α,α-terpyridine shows high catalytic performance in chemodivergent synthesis of α-alkylated arylacetonitriles in the presence of K 2 CO 3 and α-alkylated acetamides in the presence of t BuOK, respectively.
