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  • Pitfalls in the structural ...
    Shen, Shou-Mao; Appendino, Giovanni; Guo, Yue-Wei

    Natural product reports, 09/2022, Volume: 39, Issue: 9
    Journal Article

    Covering: July 2010 to August 2021 This article summarizes more than 200 cases of misassigned marine natural products reported between July 2010 and August 2021, sorting out errors according to the structural elements. Based on a comparative analysis of the original and the revised structures, major pitfalls still plaguing the structural elucidation of small molecules were identified, emphasizing the role of total synthesis, crystallography, as well as chemical- and biosynthetic logic to complement spectroscopic data. Distinct "trends" in natural product misassignment are evident between compounds of marine and plant origin, with an overall much lower incidence of "impossible" structures within misassigned marine natural products. The article summarizes over 200 cases of misassigned MNPs, identifying major pitfalls still plaguing the structural elucidation of small molecules.