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Lu, Jian; Luo, Ling-Shan; Sha, Feng; Li, Qiong; Wu, Xin-Yan
Chemical communications (Cambridge, England), 09/2019, Volume: 55, Issue: 77Journal Article
A copper-catalyzed enantioselective alkynylation between terminal alkynes and pyrazole-4,5-diones has been developed. With 2.5 mol% CuI and 3 mol% chiral ligand L15 , chiral propargylic alcohols bearing a pyrazolone motif were produced in 82-99% yield and up to 98% ee. Moreover, both enantiomers of the chiral propargylic alcohols were obtained with ligands L12 and L15 , respectively. A copper-catalyzed enantioselective alkynylation between pyrazole-4,5-diones and terminal alkynes is developed, and both enantiomers of chiral propargylic alcohols can be achieved by using the ligand illustrated and its diastereomer.
