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Peer reviewed
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Reyes, Nabora S; Krasilnikov, Maria; Allen, Nancy C; Jin Young Lee; Hyams, Ben; Zhou, Minqi; Ravishankar, Supriya; Cassandras, Monica; Wang, Chaoqun; Khan, Imran; Matatia, Peri; Johmura, Yoshikazu; Molofsky, Ari; Matthay, Michael; Nakanishi, Makoto; Sheppard, Dean; Campisi, Judith; Peng, Tien
Science (American Association for the Advancement of Science), 10/2022, Volume: 378, Issue: 6616Journal Article
Senescence marker revisitedSearching for cells that express the p16INK4a tumor suppressor, which is often used as a marker of senescence during aging, Reyes et al. identified a population of fibroblasts within the stem cell niche in the lungs of young mice. When lung epithelial cells were injured with a toxic compound, they appeared to increase secretion and stimulate airway stem cells to regenerate the epithelium. The findings raise questions about whether all p16INK4a-expressing cells are senescent, and if strategies to remove such cells (because senescent cells can be harmful) could interfere with prevously unappreciated beneficial effects. —LBR
