Recently, Internet of Things (IoT) and cloud computing (CC) have been widely studied and applied in many fields, as they can provide a new method for intelligent perception and connection from M2M (including man-to-man, man-to-machine, and machine-to-machine), and on-demand use and efficient sharing of resources, respectively. In order to realize the full sharing, free circulation, on-demand use, and optimal allocation of various manufacturing resources and capabilities, the applications of the technologies of IoT and CC in manufacturing are investigated in this paper first. Then, a CC- and IoT-based cloud manufacturing (CMfg) service system (i.e., CCIoT-CMfg) and its architecture are proposed, and the relationship among CMfg, IoT, and CC is analyzed. The technology system for realizing the CCIoT-CMfg is established. Finally, the advantages, challenges, and future works for the application and implementation of CCIoT-CMfg are discussed.