E-resources
Peer reviewed
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Schepis, Tommaso; Tringali, Andrea; Spada, Cristiano; Costamagna, Guido; Boškoski, Ivo
The American journal of gastroenterology, 05/2023, Volume: 118, Issue: 5Journal Article
At subgroup analysis, IPFD was associated only with an increased risk of acute biliary pancreatitis, whereas the other etiologies were not statistically significant. Whether IPFD can be considered a risk factor for AP, should be evaluated in a prospective study involving subjects with IPFD without any history of pancreatic disease (including genetic predisposition), evaluating the incidence of AP during a long-term follow-up compared with healthy pancreas controls. Different from the conclusions of the authors of this study, we believe that fatty replacement is not the “first hit” predisposing to pancreatic disease, but the “second hit” driving to pancreatic meta-inflammation and chronic damage (Figure 1).
